Caroline Jefferies, PhD. joined the Division of Rheumatology, Department of Medicine and Department of Biomedical Sciences at Cedars Sinai as an Associate Professor in 2015. She joined Cedars from the Royal College of Surgeons in Ireland (RCSI) where she served as an Associate Professor of Immunology and Chair of Biochemistry and Immunology and Joint Chair of Molecular and Cellular Therapeutics. Dr. Jefferies has published over 50 peer-reviewed publications and serves as a reviewer and editor for many journals, including Immunity, Journal of Immunology, Clinical Immunology and Blood.

A graduate of Trinity College Dublin, Dr. Jefferies’ work has focussed on uncovering the role the innate immune response plays in the development and pathology of systemic autoimmune diseases, particularly Lupus. To this end her uncovered novel regulators of type I interferons, which are important drivers of Lupus. This work has continued at Cedars, focusing on how these pathways impact ER stress and IFN regulation and drive pathology in Lupus.